Certificate of Analysis
Purity
≥98.0%
Method
HPLC / MS
Testing
Third-Party
COA Status
Available
LL37
A research compound studied in controlled laboratory settings for scientific investigation and analytical characterization.
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Research Use Only — All products are intended strictly for laboratory research purposes and are not for human consumption. Not intended to diagnose, treat, cure, or prevent any disease.
About LL37
LL-37 is the C-terminal 37-amino acid cathelicidin peptide fragment cleaved from the human cathelicidin precursor protein hCAP-18 by serine protease activity. The peptide adopts an amphipathic α-helical secondary structure in membrane-mimicking environments, with cationic residues along one helix face and hydrophobic residues along the other — a configuration typical of membrane-active antimicrobial peptides. LL-37 is primarily expressed in neutrophils, macrophages, mast cells, and epithelial cells, and represents the sole cathelicidin in the human proteome.
Research investigations of LL-37 encompass its membrane-disruption mechanisms in model lipid bilayer systems (using CD spectroscopy and fluorescence assays), toll-like receptor (TLR) signaling modulation studies, chemotactic activity at FPRL1/FPR2 receptors in leukocyte migration assays, and investigation of its nuclear entry and intracellular gene regulatory functions in epithelial cell models. The compound is also studied for its effects on angiogenesis via VEGF receptor transactivation and as a modulator of inflammatory signaling in controlled cell culture settings.
Peptide / Compound Information
| Property | Value |
|---|---|
| Peptide Sequence | Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu-Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser |
| Molecular Formula | C205H340N60O53S2 |
| Molecular Weight | 4,493.4 g/mol |
| CAS Number | 154947-66-7 |
| Synonyms | Cathelicidin LL-37, hCAP18(134-170), CAMP (Cathelicidin Antimicrobial Peptide) |
Lyophilized Research Peptides
This product is supplied in lyophilized (freeze-dried) form — a process that extends shelf life and preserves peptide purity and structural integrity during storage. No fillers, excipients, or preservatives are used in the lyophilization process. The lyophilized powder should be reconstituted with an appropriate research-grade solvent in a controlled laboratory environment prior to use in in vitro or preclinical assay systems.
99%+
PURITY
Third Party Tested
Independently verified by ISO-accredited laboratories. Batch-specific COAs available on request.
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GMP Manufacturing Standards
Synthesized in registered facilities following Good Manufacturing Practices with full chain-of-custody documentation.
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Same-day fulfillment on qualifying orders. Secure cold-chain packaging. Domestic and international research shipping.
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Zero Fillers or Additives
Pure active compounds only. Lyophilized without fillers or preservatives. Composition independently verified.
Scientific Content Review
All technical product descriptions, molecular data, and research context on this page have been prepared with reference to published scientific literature and PubChem compound databases. Content is intended for informational purposes in a research catalog context and does not constitute medical advice or claim therapeutic efficacy.
LL37 is a research compound available for controlled laboratory investigation and scientific study. This product is intended strictly for in vitro research, preclinical investigation, and analytical characterization by qualified researchers. Not for human consumption.
Category
Other
Purity
≥98.0%
Available Sizes
5MG
COA
Available