Certificate of Analysis
Purity
≥98.0%
Method
HPLC / MS
Testing
Third-Party
COA Status
Available
IGF-DES
A research compound studied in controlled laboratory settings for scientific investigation and analytical characterization.
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Research Use Only — All products are intended strictly for laboratory research purposes and are not for human consumption. Not intended to diagnose, treat, cure, or prevent any disease.
About IGF-DES
IGF-1 DES (des(1-3)IGF-1) is a naturally occurring truncated form of insulin-like growth factor-1 (IGF-1), in which the first three N-terminal amino acids (Gly-Pro-Glu) are removed. This truncation eliminates a significant portion of the binding domain for IGF binding proteins (IGFBPs) — particularly IGFBP-3 — while preserving full agonist activity at the IGF-1 receptor (IGF-1R). As a result, DES-IGF-1 exhibits markedly reduced affinity for circulating IGFBPs in vitro (approximately 50-fold lower than full-length IGF-1), potentially increasing the free, biologically active fraction in experimental models.
Research interest in IGF-1 DES centers on its use as a tool to study IGF-1R signaling independently of IGFBP-mediated buffering, enabling investigation of receptor activation pharmacology without confounding IGFBP competition. Research applications include IGF-1R binding kinetics determination, downstream IRS-1/PI3K/Akt and Ras/ERK1/2 signaling pathway characterization in cell models, and comparative potency studies between full-length IGF-1 and IGFBP-resistant truncated variants. For qualified laboratory research use only.
Peptide / Compound Information
| Property | Value |
|---|---|
| Peptide Sequence | GPE-IGF-1: des(1-3) N-terminal truncated IGF-1 (68 AA from position 4 onward of full-length IGF-1) |
| Molecular Formula | C319H503N95O94S6 |
| Molecular Weight | 7,371.4 g/mol |
| CAS Number | 112603-37-9 |
| Synonyms | IGF-1 DES(1-3), Truncated IGF-1, des(1-3)IGF-1, IGF-DES |
Lyophilized Research Peptides
This product is supplied in lyophilized (freeze-dried) form — a process that extends shelf life and preserves peptide purity and structural integrity during storage. No fillers, excipients, or preservatives are used in the lyophilization process. The lyophilized powder should be reconstituted with an appropriate research-grade solvent in a controlled laboratory environment prior to use in in vitro or preclinical assay systems.
99%+
PURITY
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Independently verified by ISO-accredited laboratories. Batch-specific COAs available on request.
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Synthesized in registered facilities following Good Manufacturing Practices with full chain-of-custody documentation.
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Pure active compounds only. Lyophilized without fillers or preservatives. Composition independently verified.
Scientific Content Review
All technical product descriptions, molecular data, and research context on this page have been prepared with reference to published scientific literature and PubChem compound databases. Content is intended for informational purposes in a research catalog context and does not constitute medical advice or claim therapeutic efficacy.
IGF-DES is a research compound available for controlled laboratory investigation and scientific study. This product is intended strictly for in vitro research, preclinical investigation, and analytical characterization by qualified researchers. Not for human consumption.
Category
Other
Purity
≥98.0%
Available Sizes
2MG
COA
Available